Micromethods
Micromethods

Save time, reduce costs and simplify your analyses

Low micro volumes ideally fit the automated workflows of the robotic PAL Systems and are compatible for the direct application to analytical instruments.

 

Liquid extraction - LLE/SLE

Liquid/liquid extractions (LLE) but also solid/liquid extractions (SLE) are widely used sample pre-preparation methods in analytical laboratories.

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Micro-SPE

Typical applications are for the QuEChERS pesticides analysis, veterinary drug control, filtration of life science samples, and more.

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Solid Phase Micro-Extraction

Solid phase micro-extraction is a highly popular solventless and a true green analysis extraction technique.

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Static & Dynamic Headspace

Headspace analysis with the PAL System delivers many strong benefits for your laboratory. The best benefit is the unique tool-based solution.

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Related Content

Walk away QuEChERS extracts clean-up
Videos

Walk away QuEChERS extracts clean-up

See this detailed video of the µSPE workflow for the clean-up of raw pesticides extract. The µSPE cartridge is operated in scavenger mode eluting the pesticides in a clean extract. The matrix is kept on the sorbent material. The cleaned extract can be injected without waiting time online for LC-MS or GC-MS analysis. All samples are treated on the same time axis for highest reliability.

Advantages of automated and miniaturized µ-SPE clean-up in pesticides residues analysis
Webinars

Advantages of automated and miniaturized µ-SPE clean-up in pesticides residues analysis

Recent developments in pesticides analysis extend the well-established methods to higher productivity and reliability while minimizing consumption and exposition to harmful chemicals. A workflow was developed that allows automatic preparation of calibration standards, automatic sample dilution, and automatic clean-up of sample extracts on one instrument, showing that miniaturized automated solutions are reducing errors, improving analytical consistency and protecting the environment in one convenient approach.

Presented by:

Thomi Preiswerk, Senior Account Manager, CTC Analytics AG

Gwen Lim , Specialist for automated sample preparation, CTC Analytics

Ederina Ninga, Postdoc, Research Group for Analytical Food Chemistry, Danish Technical University 

 

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Automated Sample Preparation for pesticides using QuEChERS extraction and cleanup
Webinars

Automated Sample Preparation for pesticides using QuEChERS extraction and cleanup

The QuEChERS analysis method is a popular solid-phase extraction method used for the analysis of pesticide residues in food. However, there are analytical and logistical limitations during cleanup. The Webinar shows two workflow variations for high sample throughput in online GC-MS and LC-MS analysis. 

Presented by:
Hans-Joachim Huebschmann, PhD, Gwen Lim and Chiew Mei Chong, CTC Analytics AG

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Automated Sample Preperation for LC-MS and GC-MS -Solutions for Food and Environmental Analysis
Webinars

Automated Sample Preperation for LC-MS and GC-MS -Solutions for Food and Environmental Analysis

In this presentation we want to discuss an important development and a demand from analytical laboratories about the standardization and the automation of sample preparation procedures for food safety, environmental, the forensic or pharmaceutical analysis.

Presented by:
Hans-Joachim Huebschmann, PhD

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How to save money and time doing Sample Prep
Webinars

How to save money and time doing Sample Prep

  • Learn about the importance of fundamental aspects of sample preparation and modern, sustainable sample preparation technologies
  • Find out about the latest innovations in sample preparation in environmental analysis
  • Learn about new materials used in sample preparation

Presented by:
Günter Boehm, PhD, VP Sample Prep Solutions, CTC Analytics AG

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Fully Automated QuEChERS Extraction and Clean-up of Organophosphate Pesticides in Orange Juice
Publications

Fully Automated QuEChERS Extraction and Clean-up of Organophosphate Pesticides in Orange Juice

Chiew Mei Chong1, Hans-Joachim Hübschmann2

1 CTC Analytics Pte. Ltd., Singapore.
2 HANS Analytical Solutions, Osaka, Japan.

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Analysis of Highly Polar Pesticides
Application Notes

Analysis of Highly Polar Pesticides

Micro-SPE (μSPE) emerged as an automated green micromethod for sample preparation and clean-up in food safety, proteomics, forensic, environmental and analysis since more than ten years. Applications are wideranging and cover drugs, environmental contaminants, and, in particular, the extract clean-up in multiresidue pesticide analysis. The automation of the μSPE sample preparation steps led to the desired standardization of the applied sorbent materials for extract clean-up for the large variety of food commodities, an increase in sample throughput, and the welcome potential for offline and online hyphenation with GC-MS, LC-MS or even IC analysis.

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Analysis of Volatile Organic Compounds in Durian by Static Headspace and ITEX-DHS GC-MS
Application Notes

Analysis of Volatile Organic Compounds in Durian by Static Headspace and ITEX-DHS GC-MS

The distinctive onion and fruity odorous compounds were detected by both static headspace and ITEX-DHS techniques.

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Automated Mini‑Column Solid‑Phase Extraction Cleanup for High‑Throughput Analysis of Chemical Contaminants in Foods
Application Notes

Automated Mini‑Column Solid‑Phase Extraction Cleanup for High‑Throughput Analysis of Chemical Contaminants in Foods

This study demonstrated the application of an automated high-throughput mini-SPE cleanup for the  analysis of pesticides and environmental contaminants in QuEChERS extracts of foods.

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Automated SPE clean-up of QuEChERS extracts for multi-residue pesticide analysis
Application Notes

Automated SPE clean-up of QuEChERS extracts for multi-residue pesticide analysis

This note covers the development and use of miniaturized cSPE for QuEChERS.

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Fully Automated QuEChERS Extraction and Clean-up for homogeneous matrices
Application Notes

Fully Automated QuEChERS Extraction and Clean-up for homogeneous matrices

A fully automated, true green analytical method, for high sensitivity and precision pesticide analysis. This report describes for the first time a fully automated QuEChERS extraction and clean-up workflow for homogeneous matrices like fruit juices, demonstrated for orange juice.

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Routine Pesticide Analysis using Micro-SPE
Application Notes

Routine Pesticide Analysis using Micro-SPE

This report presents for the first time the application of µSPE for the clean-up of the raw extracts using ethyl acetate as extraction solvent for pesticides from different also more complex food commodities.

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QuEChERS Compendium
eBooks

QuEChERS Compendium

Automated μSPE cleanup for GC-MS or LC-MS analysis of pesticides and environmental contaminants in QuEChERS extracts of foods

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PAL Method Composer
Brochures

PAL Method Composer

Methods in minutes

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PAL QuEChERS
Brochures

PAL QuEChERS

Automated μSPE cleanup for GC-MS or LC-MS analysis of pesticides and environmental contaminants in QuEChERS extracts of foods

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Automated Clean-up and Analysis of Pesticides in Spices by Mini-SPE
Posters

Automated Clean-up and Analysis of Pesticides in Spices by Mini-SPE

The automated mini-SPE clean-up workflow improved the efficiency of analysis and significantly increased the sample throughput.

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Automated Clean-up of PAH in Sunflower Oil for GC-MS
Posters

Automated Clean-up of PAH in Sunflower Oil for GC-MS

The objective was to establish an automated µSPE clean-up procedure for PAH analysis in edible oils, here used sunflower oil. We were using the greater concepts of Green Analytical Chemistry and automation.

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Automated Clean-up of QuEChERS Extracts for GC-MS and LC-MS
Posters

Automated Clean-up of QuEChERS Extracts for GC-MS and LC-MS

A fully automated, true green analytical method, for high sensitivity and precision pesticide analysis. This report describes for the first time a fully automated QuEChERS extraction and clean-up workflow for homogeneous matrices like fruit juices, demonstrated for orange juice.

Read more
Characterization of the New PAL Micro-SPE Cartridge for Pesticides Extract Clean-up
Posters

Characterization of the New PAL Micro-SPE Cartridge for Pesticides Extract Clean-up

Since more than ten years micro-SPE (µSPE) emerged as a micromethod for sample preparation and clean-up in food safety, proteomics, forensic, environmental and analysis. Applications are wide-ranging and cover drugs, environmental contaminants, and, in particular, the QuEChERS extract cleanup in multiresidue pesticide analysis. The automation of the µSPE sample preparation steps led to the desired increase in sample throughput, unification of the used sorbent materials for food commodities, and the potential for the online hyphenation with GC-MS and LC-MS instrumentation.
 

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Direct injection of μ-SPE extracts into LCMS: automated clean-up meets high-throughput analysis
Posters

Direct injection of μ-SPE extracts into LCMS: automated clean-up meets high-throughput analysis

The μSPE direct injection workflow has been optimized and used for the high-throughput cleanup of liquid samples. Several μ-SPE cartridges are currently being tested by LCMS for the cleanup of complex sample matrices containing various pesticides and drugs, in order to further validate the performance of the direct μ-SPE-LCMS workflow in different use cases.

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Evaluation of μ-solid phase extraction for the analysis of pesticide residues in cereals
Posters

Evaluation of μ-solid phase extraction for the analysis of pesticide residues in cereals

The μ-SPE clean-up efficiency was demonstrated in the removal of matrixinterfering components and in the recovery of pesticides.

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Fully Automated QuEChERS for Organochlorine and Organophosphate Pesticides in Tomato Juice and Red Wine
Posters

Fully Automated QuEChERS for Organochlorine and Organophosphate Pesticides in Tomato Juice and Red Wine

Using PAL Robotic Tool Change (RTC) system, a fully automated QuEChERS was developed for the extraction and clean-up of organochlorine and organophosphate pesticides from homogeneous samples. The automated QuEChERS workflow includes extraction with acetonitrile, salting out with
saturated sodium chloride solution and the clean-up with PAL μSPE prior to injection into the GC-MS/MS for analysis.

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Time and Money Savings by the Implementation of Automated μSPE for Cleanup of QuEChERS Extracts of Veterinary Drugs
Posters

Time and Money Savings by the Implementation of Automated μSPE for Cleanup of QuEChERS Extracts of Veterinary Drugs

In this poster presentation, we compare two workflows for the cleanup of multi-class veterinary drugs in animal tissue matrices, based on the Thermo Scientific™ VetDrugs Explorer Collection (P/N VDX-TSQ02-10001, Thermo Fisher Scientific, Waltham MA, USA).

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