Reference Literature


List of peer reviewed articles citing PAL System, ordered by market segments, June 2018


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Latest highlights: Cancer research using ITEX Dynamic Headspace / Steven Lehotay and team on QuEChERS sample cleanup by micro-SPE


Stefano Tiziano et al. studied the metabolomic signature of brain cancer.

Amongst other tools they have used GC-MS with ITEX Dynamic Headspace Extraction.

Read the abstract of this article.

Conclusions from the article of Lehotay et al.:
The automated mini-SPE cleanup coupled with LPGCMS/MS analysis not only achieved high quality results
for diverse type of analytes and foods, the approach also enabled reliable, high-throughput operations without much labor or instrument maintenance.

Read the open access article in Chromatographia.




Life Science

Keywords: adult glioblastoma; magnetic resonance spectroscopy; mass spectrometry; metabolomics; paediatric glioblastom; GC-MS, ITEX Dynamic Headspace

Mol. Carcinog. 2017 Jun 15. doi: 10.1002/mc.22694. [Epub ahead of print]

Keywords: surface sampling, LC-MS, quantitative tissue distribution, drug discovery

Anal Chem, 2016, 88, 11813-20

Keywords: SPME, biocompatible, complex matrices, in-tube, single drop

Anal Chem, 2016, DOI: 10.1021/acs.analchem.6b03160

Keywords: Volatile organic compounds, VOC, GC-TOF–MS, Metabolomics, Headspace, ITEX, Allium

BMC Res Notes, 2016, 9, 133

Keywords: proteomics, cerebrospinal fluid, CSF, throughput, robustness, RP-LC MS/MS

Anal Chem 2015, 87, 10755-10761

Keywords: proteomics, coverage phosphorylated peptides, phospho petides, titanium dioxide microcolum

Anal Chem 2015, 87, 10213-2

Keywords: droplet-based liquid microjunction surface sampling, complex matrix samples, chemical information from single spot

Anal Bioanal Chem,  2015, 407, 2117-25

Keywords: multiplexed quantitative analysis method, carboxylic acids, liquid chromatography high resolution mass spectrometry, LC-MS

Anal Chem, 2014, 86, 4402-4408

Keywords: Fecal analysis, lipidomics, mass spectrometry, liquid chormatography, high pressure cycling LC/MS, premature infant, neonate

Anal Chem,  2013, 85, 1114−1123

Keywords: immunosuppressant, blood samples, in-vitro diagnostic (IVD)- mass spectrometric immunosuppressant assay, LC/MS

Ther Drug Monit, 2013, 35, 129-32

Metabolic Profiling of Oxidized Lipid-Derived Volatiles in Blood by Gas Chromatography/Mass Spectrometry with In-Tube Extraction (ITEX)

Mass Spectrometry 2013, 2, A0018

Keywords: Scintillation counter, radiolabeling, UHPLC

J Chromatogr B Analyt Technol Biomed Life Sci. 2006; 844(1):96-103

Keywords: High throughput screening, LC/MS

J Biomol Screen. 2006 April,11 (3): 318-22. EPub 2006 Feb 20.

Keywords: High throughput Screening, LC/MS

Anal. Chem. 2005, 77, 1905-1910

Keywords: High throughput screening, LC/MS

J Biomolecular Screening 2004: 9, 498-505

Food & Food Safety

Keywords: pesticides, veterinary drugs, environmental contaminanst, QuEChERS, GC-MS, LC-MS, beef

J. Agric. Food Chem. (2020)

Keywords: Allergenic food, plant allergen (soy, sesame, lupine), LC-MS/MS, quantification of allergenic plant traces, food labeling

Food Sci. Technol. (2016), 74, 286-93

Keywords: High-throughput automation, solid-phase extraction, cleanup, pesticide residue analysis, QuEChERS sample preparation, fast GC-MS/MS, analyte protectants, environmental contaminants, foods

Chromatographia (2016) DOI:10.1007/s10337-016-3116-y

Read the open access article

Keywords: Sulfur, nitrogen, volatile compound, amino acid, odor-active compound, sausage, solvent assisted flavor evaporation

Food Chem, 190 (2016) 657-664

Keywords: QuEChERS, micro SPE, LC-MS/MS, ITSP, µSPE, Z-Sep, zirconia, pesticide, multiresidue, avocado, citrus

J Agric Food Chem, 2015, 63(21) 5107-19

Keywords: White wine, aroma compounds, vintage influence, ITEX, GC/MS

Bulletin UASVM Food Science and Technology 72(1) / 2015  (OPEN ACCESS)

Keywords: 3-sec-Butyl-2-methoxypyrazine, heart-cutmultidimensional gas chromatography, comprehensive two-dimensional gas chromatography, mass spectrometric detection, enantiodifferentiation

Anal. Bioanal. Chem. 2015, 407, 253-63

Keywords: ITEX, microextraction, GC/MS, volatile constituents, beer varieties

J. Agric. Food Chem. 2014, 62 (14), 3081–3091

Keywords: Anti-oxidant capacity, in-tube extraction ITEX, PCA, phenolic compounds, tomatoes, volatiles

Phytochem. Anal. 2014, 25 (2), 161-9

Keywords: carotenoids, orbitrap, ionization, fragmentation, identification

J. Mass Spectrom. 2013, 48, 740-754

Keywords: GC-MS, in-tube extraction ITEX, principal component analysis, volatiles, sea buckthorn fruit

Phytochem. Anal. 2013, 24, 319-328

Keywords: compound-specific isotope Analysis (CSIA), high-temperature reversed-phase liquid chromatography isotope ratio mass spectrometry, HT-RPLC/IRMS

Anal. Chem. 2012, 84, 2805−2810

Keywords: wine aroma compounds, odorant composition, GC/MS

J Agric Food Chem. 2012; 60:5045-56


Keywords: µSPE, liquid-liquid extraction, chemical warfare agents, automation, sample handling, sample preparation

Separations 2019, 6, 49 (OPEN ACCESS)

Keywords: continous flow system, inline analytics, critical process parameters,  reaction process, Claisen rearrangement
Org. Process Rev. Dev, 2014, 18 (11), 1315–1320

Keywords: compound-specific isotope analysis, steroids, isotope ratio mass spectrometry, LC/IRMS

Anal. Chem. 2014, 86, 2297−2302

Keywords: microwave extraction, surfactant, aliphatic hydrocarbons, rock, in-tube extraction, ITEX, geochemical evaluation

Analytica Chimica Acta 691 (2011) 48–55


Keywords: Cigarette butts, PAHs leachate, naphtalene, fluorene, SPME Arrow

Environmental Pollution 259 (2020) 113916

Keywords: Aerial drone; Miniaturized air sampling systems; SPME Arrow; ITEX; Sampler;
Sampling accessories; Air sampling

J Chromatogr A, 1597 (2019) 202-208 (OPEN ACCESS)

Keywords: PAL SPME Arrow, SPME, Solid-Phase Microextraction, PDMS, PAH, water

Anal. Bioanal. Chem. 2016, 408, 943-952

Keywords: pressure-balanced cold fiber SPME, Polycyclic Aromatic Hydrocarbon, PAH, sediment

Anal. Chem.; 2016, 88 , pp 8936–8941

Solid phase microextraction Arrow for the sampling of volatile amines in wastewater and atmosphere

Keywords: SPME Arrow, Solid phase microextraction, Dimethylamine, Trimethylamine, Wastewater, Atmosphere

J. Chromatography A, 1426 (2015) 56-63

Keywords: In-tube extraction, ITEX, ITEX DHS, method development, parameter optimization

Anal. Bioanal. Chem. 2015, 407, 6827-6838

Keywords: GC/IRMS, compound-specific stable isotope analysis, hydron and carbon isotope ratio mass spectrometry, headspace sampling, BTEX, MTBE

Anal Chem. 2015 ; 87 :951-9. doi: 10.1021/ac503229e

Keywords: On-line solid phase extraction, SPE, large volume injection, gas chromatography, mass spectrometry, human blood, PCBs, polychlorinated biphenyls, organochlorine pesticides

J. Chrom. B (2014), 945-946, 217-224

Keywords: Dispersive LLE, phtalate esters, GC-MS

Anal Chem. 2014;86 3743-9

Keywords: Carbon nanotubes, in-tube microextraction, design of experiment GC-MS, VOCs, water samples

Anal Bioanal Chem (2013) 405:8387–8395


Keywords: cigarette smoke exposure, nicotin, metabolite, quantification cotinine, ITSP, µSPE, LC/MS

J. Chromatogr Sci. 2013; 52 (4) 351-6

Keywords: immunosuppressant, blood samples, in-vitro diagnostic (IVD)- mass spectrometric immunosuppressant assay, LC/MS

Ther Drug Monit 2013 35(1): 129-32

Keywords: Amino acids, marker panels, metabolomics, modeling, pancreatic cancer, LC-MS

Metabolomics (2013) 9:677-687

Keywords: coronary artery bypass grafting, papaverine in plasma, HTS high-throughput screening, LC-MS/MS

Heart Surg Forum. 2013 Oct, 16(5):E266-70

J Steroid Biochem & Mol Biol 129 (2012) 129– 138


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