Reference Literature
List of peer reviewed articles citing PAL System, ordered by market segments, June 2018
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Latest highlights: Cancer research using ITEX Dynamic Headspace / Steven Lehotay and team on QuEChERS sample cleanup by micro-SPE
Stefano Tiziano et al. studied the metabolomic signature of brain cancer.
Amongst other tools they have used GC-MS with ITEX Dynamic Headspace Extraction.
Read the abstract of this article.
Conclusions from the article of Lehotay et al.:
The automated mini-SPE cleanup coupled with LPGCMS/MS analysis not only achieved high quality results
for diverse type of analytes and foods, the approach also enabled reliable, high-throughput operations without much labor or instrument maintenance.
Read the open access article in Chromatographia.

Life Science
Keywords: phosphoproteome, fractionation, 2D LC
Anal. Chem. 2019 91 (15), 9707-9715
Keywords: adult glioblastoma; magnetic resonance spectroscopy; mass spectrometry; metabolomics; paediatric glioblastom; GC-MS, ITEX Dynamic Headspace
Mol. Carcinog. 2017 Jun 15. doi: 10.1002/mc.22694. [Epub ahead of print]
Keywords: surface sampling, LC-MS, quantitative tissue distribution, drug discovery
Anal Chem, 2016, 88, 11813-20
Keywords: SPME, biocompatible, complex matrices, in-tube, single drop
Anal Chem, 2016, DOI: 10.1021/acs.analchem.6b03160
Keywords: Volatile organic compounds, VOC, GC-TOF–MS, Metabolomics, Headspace, ITEX, Allium
BMC Res Notes, 2016, 9, 133
Keywords: proteomics, cerebrospinal fluid, CSF, throughput, robustness, RP-LC MS/MS
Anal Chem 2015, 87, 10755-10761
Keywords: proteomics, coverage phosphorylated peptides, phospho petides, titanium dioxide microcolum
Anal Chem 2015, 87, 10213-2
Keywords: droplet-based liquid microjunction surface sampling, complex matrix samples, chemical information from single spot
Anal Bioanal Chem, 2015, 407, 2117-25
Keywords: multiplexed quantitative analysis method, carboxylic acids, liquid chromatography high resolution mass spectrometry, LC-MS
Anal Chem, 2014, 86, 4402-4408
J Am Soc Mass Spectrom 2013; 24(10): 1584-92
Keywords: metabolomics, profiling, orthogonal separation, column switching
Anal Chem, 2014, 86, 4145-4150
Keywords: Fecal analysis, lipidomics, mass spectrometry, liquid chormatography, high pressure cycling LC/MS, premature infant, neonate
Anal Chem, 2013, 85, 1114−1123
Keywords: immunosuppressant, blood samples, in-vitro diagnostic (IVD)- mass spectrometric immunosuppressant assay, LC/MS
Ther Drug Monit, 2013, 35, 129-32
J. Am. Soc. Mass Spectrom. (2013) 24;1016-1025
Metabolomics (2013) 9: 564–574
Metabolic Profiling of Oxidized Lipid-Derived Volatiles in Blood by Gas Chromatography/Mass Spectrometry with In-Tube Extraction (ITEX)
Mass Spectrometry 2013, 2, A0018
Anal. Chem. 2012, 84, 4942−4949
Bioanalysis (2012) 4(11), 1327–1335
J Thyroid Res. 2012;2012:815079
Int J Mass Spectrom. 2011, 307, 105–111
Int J Mass Spectrom. 2011; 302(1-3): 59–68
J Pharm Biomed Anal 55 (2011) 949–956
Int. J. Mass Spec, 302, 2011, 139–148
Anal. Chem. 2009, 81, 9225–9232
Anal. Chem. 2009, 81, 7677–7694
Keywords: Scintillation counter, radiolabeling, UHPLC
J Chromatogr B Analyt Technol Biomed Life Sci. 2006; 844(1):96-103
Keywords: High throughput screening, LC/MS
J Biomol Screen. 2006 April,11 (3): 318-22. EPub 2006 Feb 20.
Keywords: High throughput screening, LC/MS
Rapid Commun Mass Spectrom. 2006; 20(2): 291-7
Keywords: High throughput Screening, LC/MS
Anal. Chem. 2005, 77, 1905-1910
Keywords: High throughput screening, LC/MS
J Biomolecular Screening 2004: 9, 498-505
Keywords: SPME, GC-MS
J Steroid Biochem Mol Biol. 2003 Feb; 81(2-3):383-91
Keywords: Ethinylestradiol, derivatization dansyl chloride, LC/MS
Anal Chem. 2002, 74(16), 4136-44

Food & Food Safety
Keywords: pesticides, veterinary drugs, environmental contaminanst, QuEChERS, GC-MS, LC-MS, beef
J. Agric. Food Chem. (2020)
Keywords: Allergenic food, plant allergen (soy, sesame, lupine), LC-MS/MS, quantification of allergenic plant traces, food labeling
Food Sci. Technol. (2016), 74, 286-93
Keywords: High-throughput automation, solid-phase extraction, cleanup, pesticide residue analysis, QuEChERS sample preparation, fast GC-MS/MS, analyte protectants, environmental contaminants, foods
Chromatographia (2016) DOI:10.1007/s10337-016-3116-y
Keywords: Sulfur, nitrogen, volatile compound, amino acid, odor-active compound, sausage, solvent assisted flavor evaporation
Food Chem, 190 (2016) 657-664
Keywords: QuEChERS, micro SPE, LC-MS/MS, ITSP, µSPE, Z-Sep, zirconia, pesticide, multiresidue, avocado, citrus
J Agric Food Chem, 2015, 63(21) 5107-19
Keywords: PAHs, polycyclic aromatic hydrocarbons, 2D LCxGC-MS, food
Anal Chem 2015 87(12):6195-203
Keywords: White wine, aroma compounds, vintage influence, ITEX, GC/MS
Bulletin UASVM Food Science and Technology 72(1) / 2015 (OPEN ACCESS)
Keywords: 3-sec-Butyl-2-methoxypyrazine, heart-cutmultidimensional gas chromatography, comprehensive two-dimensional gas chromatography, mass spectrometric detection, enantiodifferentiation
Anal. Bioanal. Chem. 2015, 407, 253-63
Keywords: ITEX, microextraction, GC/MS, volatile constituents, beer varieties
J. Agric. Food Chem. 2014, 62 (14), 3081–3091
Keywords: Anti-oxidant capacity, in-tube extraction ITEX, PCA, phenolic compounds, tomatoes, volatiles
Phytochem. Anal. 2014, 25 (2), 161-9
Keywords: carotenoids, orbitrap, ionization, fragmentation, identification
J. Mass Spectrom. 2013, 48, 740-754
Keywords: GC-MS, in-tube extraction ITEX, principal component analysis, volatiles, sea buckthorn fruit
Phytochem. Anal. 2013, 24, 319-328
Keywords: compound-specific isotope Analysis (CSIA), high-temperature reversed-phase liquid chromatography isotope ratio mass spectrometry, HT-RPLC/IRMS
Anal. Chem. 2012, 84, 2805−2810
Keywords: ITEX, GC, wine, beer
J. Chromatography A, 1230 (2012) 1– 7
Keywords: SPME, GC-MS
J Agric Food Chem. 2012; 60: 12270−12281
Keywords: wine aroma compounds, odorant composition, GC/MS
J Agric Food Chem. 2012; 60:5045-56
Proteomics 2005, 5, 3836–3846

Chemical
Keywords: µSPE, liquid-liquid extraction, chemical warfare agents, automation, sample handling, sample preparation
Separations 2019, 6, 49 (OPEN ACCESS)
Keywords: continous flow system, inline analytics, critical process parameters, reaction process, Claisen rearrangement
Org. Process Rev. Dev, 2014, 18 (11), 1315–1320
Keywords: compound-specific isotope analysis, steroids, isotope ratio mass spectrometry, LC/IRMS
Anal. Chem. 2014, 86, 2297−2302
Keywords: microwave extraction, surfactant, aliphatic hydrocarbons, rock, in-tube extraction, ITEX, geochemical evaluation
Analytica Chimica Acta 691 (2011) 48–55

Environmental
Keywords: Cigarette butts, PAHs leachate, naphtalene, fluorene, SPME Arrow
Environmental Pollution 259 (2020) 113916
Keywords: Aerial drone; Miniaturized air sampling systems; SPME Arrow; ITEX; Sampler;
Sampling accessories; Air sampling
J Chromatogr A, 1597 (2019) 202-208 (OPEN ACCESS)
Keywords: PAL SPME Arrow, SPME, Solid-Phase Microextraction, PDMS, PAH, water
Anal. Bioanal. Chem. 2016, 408, 943-952
Keywords: pressure-balanced cold fiber SPME, Polycyclic Aromatic Hydrocarbon, PAH, sediment
Anal. Chem.; 2016, 88 , pp 8936–8941
Solid phase microextraction Arrow for the sampling of volatile amines in wastewater and atmosphere
Keywords: SPME Arrow, Solid phase microextraction, Dimethylamine, Trimethylamine, Wastewater, Atmosphere
J. Chromatography A, 1426 (2015) 56-63
Keywords: In-tube extraction, ITEX, ITEX DHS, method development, parameter optimization
Anal. Bioanal. Chem. 2015, 407, 6827-6838
Keywords: online preconcentration, SPE, LC-ESI-MS/MS, thiols, derivatization
Anal Chem. 2015; 87 :1089-96. doi: 10.1021/ac503679y
Keywords: GC/IRMS, compound-specific stable isotope analysis, hydron and carbon isotope ratio mass spectrometry, headspace sampling, BTEX, MTBE
Anal Chem. 2015 ; 87 :951-9. doi: 10.1021/ac503229e
Keywords: On-line solid phase extraction, SPE, large volume injection, gas chromatography, mass spectrometry, human blood, PCBs, polychlorinated biphenyls, organochlorine pesticides
J. Chrom. B (2014), 945-946, 217-224
Keywords: Dispersive SPE, magnetic particles
Anal Chem. 2014; 86 11070-6
Keywords: Dispersive LLE, phtalate esters, GC-MS
Anal Chem. 2014;86 3743-9
Keywords: Endocrine disrupting compounds, on-line SPE, LC-MS
Talanta 115 (2013) 349-360
Keywords: Carbon nanotubes, in-tube microextraction, design of experiment GC-MS, VOCs, water samples
Anal Bioanal Chem (2013) 405:8387–8395
Anal. Chem. 2012, 84, 8990−8995
J Chromatography A, 1268 (2012) 74– 83
Anal. Chem. 2010, 82, 7641–7648
Talanta. 2008 Mar 15; 75 (1): 111-5
Anal Bioanal Chem (2007) 387:2163–2174
Anal. Chem. 2006, 78, 5222-5226
Journal of Chromatography A, 1097 (2005) 138–147
Phytochem. Anal. 2014, 25 (2), 161-9
Anal. Chem. 2004, 76, 4756-64

Clinical
Keywords: SPME, GC-MS, VOCs, cigarette smoke
Anal Chem. 2014 Jul 15;86(14):7088-95
Keywords: cigarette smoke exposure, nicotin, metabolite, quantification cotinine, ITSP, µSPE, LC/MS
J. Chromatogr Sci. 2013; 52 (4) 351-6
Keywords: immunosuppressant, blood samples, in-vitro diagnostic (IVD)- mass spectrometric immunosuppressant assay, LC/MS
Ther Drug Monit 2013 35(1): 129-32
Keywords: Amino acids, marker panels, metabolomics, modeling, pancreatic cancer, LC-MS
Metabolomics (2013) 9:677-687
Keywords: coronary artery bypass grafting, papaverine in plasma, HTS high-throughput screening, LC-MS/MS
Heart Surg Forum. 2013 Oct, 16(5):E266-70
J Steroid Biochem & Mol Biol 129 (2012) 129– 138
Rapid Commun. Mass Spectrom. 2012, 26, 499–509
Bioanalysis. 2012 (22):2681-91
Keywords: ITEX, GC-MS
J Analytical Toxicology, 34, 2010, 113-121
Clin Chim Acta 411 (2010) 1637-1644
Keywords: 25-hydroxyvitamin D, ITSP, µSPE, LC/MS/MS,
Ann Clin Biochem 2009; 46: 226–230
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