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A close up of a blood sample connected to milestones of a fully automated workflow. From barcode reading, sample movement and preparation to analysis.

The Workflow in Action

The demonstration elegantly simulated a common laboratory workflow, showcasing the power of combined automation and integrated data management:

  1. Autonomous Retrieval: The JAG MoMa intelligently navigated to a storage location to retrieve a designated sample plate.
  2. Precision Handover: The MoMa transported and accurately delivered the plate to the PAL System.
  3. Automated Sample Prep: The PAL System received the plate, potentially scanned barcodes for identification, and performed automated sample dilutions with precision.
  4. Integrated Analysis Injection: Finally, the PAL System injected the prepared samples into the analytical instrument (e.g., LC/MS), initiating data acquisition through its direct integration with common Chromatography Data Systems (CDS). This critical link ensures a direct bridge between the physical sample, its retrieval and preparation, as well as the final analytical data.
A workflow depiction combining the capabilities of the JAG MoMa and a PAL System powered analytical platform. That can be either a GC or LC/MS System, where the PAL System takes care of the sample preparation and injection. Due to the rule-based decision making options, samples could automatically be picked up, transferred or be re-injected in a fully traceable and automated manner.

Inspiring the Fully Automated & Traceable Lab

This successful demonstration is more than just a proof-of-concept; it is a catalyst for envisioning truly end-to-end automated and traceable workflows – workflows that free up highly skilled researchers from repetitive tasks, potentially even giving them enough time to solve enduring lab mysteries, like who really left that mug in the sink.

If you are interested and would like to learn more about this type of integrated automation, do not hesitate to get in touch with us via the contact form or connect with our partners at JAG Robotics and Brechbühler AG.

Robots in the Lab: An Interview on Automation with JAG Robotics & PAL System

Beyond identifying caffeine culprits, imagine the possibilities in a high-throughput environment like a Metabolomics Core Facility:

Sample Logistics

Automated sample retrieval directly from large-scale biobanks or storage units by the JAG MoMa.

 

Intelligent Distribution

The MoMa delivers specific samples to designated PAL System workstations based on analytical needs. Rule-based missions provide flexibility to design robust workflows.

 

Complex Prep & Integrated Analysis

The PAL System executes your sample preparation protocols, i.e., automated Bligh & Dyer, Micro-SPE Clean-ups or SPME Arrow, followed by the injection into LC/MS or GC/MS instruments. The PAL System's deep integration with major CDS platforms ensures that sample information, preparation steps, and analytical results are seamlessly linked within the data system.

 

Complete Traceability

Built-in barcode scanning capabilities on the PAL System and the JAG MoMa, combined with the CDS/LIMS integration options, provide complete sample tracking and data provenance. Every step, from initial sample identification through preparation to the final result, is electronically logged, ensuring unparalleled data integrity and facilitating regulatory compliance.

 

Continuous Operation

The JAG MoMa could autonomously replenish the PAL System with necessary consumables (tips, vials, plates) and solvents, enabling uninterrupted runs. Automating these micro-logistics will free up your lab personnel for more important tasks.

 

Smart Decision Making

Based on initial analytical results acquired via the CDS, rule-based decisions could trigger subsequent actions: automatically logging results or report building, re-injecting a sample, performing further dilutions, or directing the MoMa to return analysed samples to storage.

 

 

The Next Step

The collaboration between PAL System and JAG Robotics highlights that the era of the fully automated, interconnected "smart lab" is not a distant dream but an achievable reality. By integrating specialized robotic systems like the PAL System for intricate, traceable sample handling and analysis with mobile platforms like the JAG MoMa for logistics, laboratories can significantly enhance efficiency, reproducibility, throughput, and data integrity. This integrated approach enables seamless, fully traceable sample-to-result workflows, ultimately freeing up invaluable scientist time for interpretation, discovery, and perhaps finally figuring out who keeps leaving mugs in the lab sink.

This demonstration serves as an invitation to scientists and lab managers: How could seamless, fully traceable workflow automation transform your research?

Let us know and connect with us and our partners!

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