Clinical
Clinical

Clinical

Pharmaceutical and forensic analysis deal with biological samples, typically with challenging, complex matrices. PAL Systems deliver proven workflows for the automated analysis of the active pharmaceutical ingredients, illicit drugs, toxic compounds, and also residue analysis. 

Nitrosamines in active pharmaceutical products are of high concern. The fully automated sample preparation on the PAL System with liquid/liquid injection (LLE) comprises vortexing, centrifugation and evaporation for a direct injection into LC-HRMS.

The control of residual solvents in drug products applying USP 467 standard method is the most used headspace method in pharmaceutical industry. The PAL System delivers highly precise sample preparation for headspace analysis with GC/MS.

For the analysis of illicit drugs in forensic labs often urine or hair samples are subjected to automated sample preparation on the PAL System. The dried blood spot analysis (DBS) is perfectly automated on the PAL System. Also the micro-SPE (µSPE) finds application e.g. for the analysis of psychoactive substances from serum samples, illicit drug control or TDU pain management.
 

Workflow Solutions

Discover our and our partners ready-to-go workflows.

Reference Literature

Simultaneous Analysis of 22 Volatile Organic Compounds in Cigarette Smoke Using Gas Sampling Bags for High-Throughput Solid-Phase Microextraction
Keywords: SPME, GC-MS, VOCs, cigarette smoke
Anal Chem. 2014 Jul 15;86(14):7088-95

Determination of cotinine by LC-MS-MS with automated solid-phase extraction (open access article)
Keywords: cigarette smoke exposure, nicotin, metabolite, quantification cotinine, ITSP, µSPE, LC/MS
J. Chromatogr Sci. 2013; 52 (4) 351-6

Evaluation of a novel commercial assay for the determination of cyclosporine A, tacrolimus, sirolimus and everolimus by liquid chromatography-tandem mass spectrometric assay
Keywords: immunosuppressant, blood samples, in-vitro diagnostic (IVD)- mass spectrometric immunosuppressant assay, LC/MS
Ther Drug Monit 2013 35(1): 129-32

Pancreatic carcinoma, pancreatitis, and healthy controls: metabolite models in a three-class diagnostic dilemma
Keywords: Amino acids, marker panels, metabolomics, modeling, pancreatic cancer, LC-MS
Metabolomics (2013) 9:677-687

Pharmacokinects of intraluminally administered serum papaverine for spasm prophylaxis of the internal mammery artery
Keywords: coronary artery bypass grafting, papaverine in plasma, HTS high-throughput screening, LC-MS/MS
Heart Surg Forum. 2013 Oct, 16(5):E266-70

Standardized LC–MS/MS based steroid hormone profile-analysis
J Steroid Biochem & Mol Biol 129 (2012) 129– 138

Comparison between a high-resolution single-stage Orbitrap and a triple quadrupole mass spectrometer for quantitative analyses of drugs
Rapid Commun. Mass Spectrom. 2012, 26, 499–509

Highly selective isolation and separation of 25-hydroxyvitamin D and 3-epi-25-hydroxyvitamin D metabolites from serum.
Bioanalysis. 2012 (22):2681-91

Headspace In-Tube Extraction Gas Chromatography–Mass Spectrometry for the Analysis of Hydroxylic Methyl-Derivatized and Volatile Organic Compounds in Blood and Urine
Keywords: ITEX, GC-MS
J Analytical Toxicology, 34, 2010, 113-121

Breath biomarkers for lung cancer detection and assessment of smoking related effects - confounding variables, influence of normalization and statistical algorithms
Clin Chim Acta 411 (2010) 1637-1644

A simple automated solid-phase extraction procedure for measurement of 25-hydroxyvitamin D3 and D2 by liquid chromatography-tandem mass spectrometry
Keywords: 25-hydroxyvitamin D, ITSP, µSPE, LC/MS/MS,
Ann Clin Biochem 2009; 46: 226–230

 

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