Pharmaceutical and forensic analysis deal with biological samples, typically with challenging, complex matrices. PAL Systems deliver proven workflows for the automated analysis of the active pharmaceutical ingredients, illicit drugs, toxic compounds, and also residue analysis.
Nitrosamines in active pharmaceutical products are of high concern. The fully automated sample preparation on the PAL System with liquid/liquid injection (LLE) comprises vortexing, centrifugation and evaporation for a direct injection into LC-HRMS.
The control of residual solvents in drug products applying USP 467 standard method is the most used headspace method in pharmaceutical industry. The PAL System delivers highly precise sample preparation for headspace analysis with GC/MS.
For the analysis of illicit drugs in forensic labs often urine or hair samples are subjected to automated sample preparation on the PAL System. The dried blood spot analysis (DBS) is perfectly automated on the PAL System. Also the micro-SPE (µSPE) finds application e.g. for the analysis of psychoactive substances from serum samples, illicit drug control or TDU pain management.
Discover our and our partners ready-to-go workflows.
Simultaneous Analysis of 22 Volatile Organic Compounds in Cigarette Smoke Using Gas Sampling Bags for High-Throughput Solid-Phase Microextraction
Keywords: SPME, GC-MS, VOCs, cigarette smoke
Anal Chem. 2014 Jul 15;86(14):7088-95
Determination of cotinine by LC-MS-MS with automated solid-phase extraction (open access article)
Keywords: cigarette smoke exposure, nicotin, metabolite, quantification cotinine, ITSP, µSPE, LC/MS
J. Chromatogr Sci. 2013; 52 (4) 351-6
Evaluation of a novel commercial assay for the determination of cyclosporine A, tacrolimus, sirolimus and everolimus by liquid chromatography-tandem mass spectrometric assay
Keywords: immunosuppressant, blood samples, in-vitro diagnostic (IVD)- mass spectrometric immunosuppressant assay, LC/MS
Ther Drug Monit 2013 35(1): 129-32
Pancreatic carcinoma, pancreatitis, and healthy controls: metabolite models in a three-class diagnostic dilemma
Keywords: Amino acids, marker panels, metabolomics, modeling, pancreatic cancer, LC-MS
Metabolomics (2013) 9:677-687
Pharmacokinects of intraluminally administered serum papaverine for spasm prophylaxis of the internal mammery artery
Keywords: coronary artery bypass grafting, papaverine in plasma, HTS high-throughput screening, LC-MS/MS
Heart Surg Forum. 2013 Oct, 16(5):E266-70
Standardized LC–MS/MS based steroid hormone profile-analysis
J Steroid Biochem & Mol Biol 129 (2012) 129– 138
Comparison between a high-resolution single-stage Orbitrap and a triple quadrupole mass spectrometer for quantitative analyses of drugs
Rapid Commun. Mass Spectrom. 2012, 26, 499–509
Highly selective isolation and separation of 25-hydroxyvitamin D and 3-epi-25-hydroxyvitamin D metabolites from serum.
Bioanalysis. 2012 (22):2681-91
Headspace In-Tube Extraction Gas Chromatography–Mass Spectrometry for the Analysis of Hydroxylic Methyl-Derivatized and Volatile Organic Compounds in Blood and Urine
Keywords: ITEX, GC-MS
J Analytical Toxicology, 34, 2010, 113-121
Breath biomarkers for lung cancer detection and assessment of smoking related effects - confounding variables, influence of normalization and statistical algorithms
Clin Chim Acta 411 (2010) 1637-1644
A simple automated solid-phase extraction procedure for measurement of 25-hydroxyvitamin D3 and D2 by liquid chromatography-tandem mass spectrometry
Keywords: 25-hydroxyvitamin D, ITSP, µSPE, LC/MS/MS,
Ann Clin Biochem 2009; 46: 226–230
Automated Determination of Drugs of Abuse in Hair Samples
Hair testing is a powerful tool routinely used for the detection of drugs of abuse in forensic and toxicology applications.
Read more
Automated Parallel Derivatization Strategy with Broad Metabolite Coverage Coupled to SWATH/MS Data Acquisition for Qualitative and Quantitative Analysis
Due to the high dynamic range of different metabolites, SWATH/MS data acqusition allows the quatification on both precursor and product ion level including flexibility of the quantifier choice.
Read more
PAL LC-MS Tools
Three new LC-MS Tools, all equipped with Smart Syringes.
Read more
Automated Sample Prep Workflows: Save money and time
This compendium on instrumental sample preparation showcases the many proven solutions of automated sample preparation workflows for food, environmental, pharma, life science analysis, and beyond.
Read more
Static and Dynamic Headspace Analysis
Read more
Novel Automated Sample Clean-up: First Comprehensive Evalulation of Different Filtration Devices for x-y-z Robots
In our study we evaluate the available filtration options for x-y-z robots and some not-yet commercially available filtration devices prototypes.
Read more
Untargeted 2DxLC-Mass Spectrometry using SWATH-DIA-Based Workflow for the Characterization of Lipid Profiles in Plasma Samples
The use of lipidomic analyses based on LC-mass spectrometry has become widespread due to its sensitivity and specificity which provides a broader picture of lipid profiles in biofluids. In this work, we combined an automated sample extraction and a two-dimensional liquid chromatography (2DxLC) system with HILIC-based class separation followed by an orthogonal reverse-phase chromatography with an untargeted SWATH-DIA workflow to accurately annotate phosphatidylcholines (PC), lysophosphatidylcholine (LPC) and etherphosphatidylcholines (PC O-) in human plasma samples.
Read more
Automated Parallel Derivatization of Metabolites
For metabolite profiling chemical derivatization has been used to improve MS sensitivity and LC retention. However, for multi-analytes quantification, the number of available isotopically labelled internal standards is limited. And, there is no single workflow which can provide large-scale metabolomics coverage in particular for polar metabolites.
Presented by:
Prof. Gerard Hopfgartner, Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva
Read more
How to save money and time doing Sample Prep
- Learn about the importance of fundamental aspects of sample preparation and modern, sustainable sample preparation technologies
- Find out about the latest innovations in sample preparation in environmental analysis
- Learn about new materials used in sample preparation
Presented by:
Günter Boehm, PhD, VP Sample Prep Solutions, CTC Analytics AG
Read more
