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A single-sample workflow for joint metabolomic and proteomic analysis ofclinical specimens
Posters

A single-sample workflow for joint metabolomic and proteomic analysis ofclinical specimens

Integrating proteomic and metabolomic data enhances ourunderstanding of biological processes and diseasemechanisms. Traditional multi-omics workflows often requireseparate sample processing, leading to increased variability.To address this, we developed MTBE-SP3, an optimizedsingle-sample workflow that combines a 75% EtOH/MTBEmetabolite extraction with automated single-pot solid-phase-enhanced sample preparation for proteins.

Equip your PAL System for PFAS Analysis

Equip your PAL System for PFAS Analysis

Measuring PFAS is challenging due to their persistence, complex chemical nature, and presence at extremely low levels (parts per trillion) in environmental samples. Rigorous sample preparation, advanced analytical instrumentation, and robust quality control are essential for reliable PFAS quantification.

PAL System focusses on PFAS-free tubing, tools, and modules enabling:

  • Fully automated workflows
  • Specialized LC/MS tools
  • Multi valve setups for increased productivity using online SPE
  • μSPE clean-ups for miniaturized workflows
High-throughput Analysis of 1,4-Dioxane in Drinking Water using SPME Arrow–Trap with Multi-Step Enrichment
Application Notes

High-throughput Analysis of 1,4-Dioxane in Drinking Water using SPME Arrow–Trap with Multi-Step Enrichment

This application note showcases Solid Phase Micro Extraction (SPME) Arrow-trap technology, combined with multi-step enrichment (MSE) on the PAL3-Centri® platform and gas chromatography/mass spectrometry (GC/MS), to analyze 1,4-dioxane in water samples. The method successfully detects 1,4-dioxane at levels as low as 0.01 μg/L (10 ppt), surpassing the detection limits required by German REACH and US EPA regulations.

Advancing PFAS Analysis - Robotic Automation and Streamlined LC/MS Workflows
Webinars

Advancing PFAS Analysis - Robotic Automation and Streamlined LC/MS Workflows

To support the scientific community and advance PFAS analysis we are proud to offer a webinar on this topic.

Key topics:

  • PFAS Fundamentals: Learn about the chemistry and significance of PFAS compounds.
  • Sample Preparation Challenges: Understand current hurdles, regulations and best practices in PFAS extraction and purification.
  • Automated LC/MS Workflows: Get an overview on automated workflows and see how PAL System integrates with LC/MS to optimize sample preparation and injection.
  • Deep Dive: Explore online SPE for PFAS analysis.
Fully Automated Sample Preparation and Untargeted 2D-LC-Mass Spectrometry Workflow for Glycerophospholipid Analysis in Plasma
Posters

Fully Automated Sample Preparation and Untargeted 2D-LC-Mass Spectrometry Workflow for Glycerophospholipid Analysis in Plasma

We developed an integrated workflow combining HILIC-LC-SWATH-MS for quantitative analysis and 2D-LC HILIC x RPLC DDA-EAD/MRMHR-EAD for qualitative characterization of complex lipidomes,particularly glycerophospholipids.

Streamlining Metabolomic Analyses with Automated Derivatization and Injection Workflows
Application Notes

Streamlining Metabolomic Analyses with Automated Derivatization and Injection Workflows

Metabolites, the dynamic molecules reflecting cellular processes, hold the potential for understanding health, disease, and
biological systems. To unlock this potential, metabolomic analyses require precise and reliable analytical methods. This App Note
explores the workflow of the Metabolomics Core Technology Platform (MCTP), a core facility of Heidelberg University (Germany),
discussing their semi-automated analysis for untargeted metabolomics and ¹³C tracing studies via gas chromatography-mass
spectrometry (GC/MS).

PFAS-free Upgrade Kits
Brochures

PFAS-free Upgrade Kits

Equip your PAL Systems for PFAS Analysis with PFAS-free Upgrade Kits and minimize PFAS Background.

How to install the SPME MultiGuide in SPME Fiber Tools

PAL Method Composer - Software Demonstration and Method Deep Dive into FAMEs
Webinars

PAL Method Composer - Software Demonstration and Method Deep Dive into FAMEs

Would you like to automate your sample preparation workflow or injection (LC or GC)?

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