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Micromethods - Automated µSPE Cleanup for High-Throughput QuEChERS Analysis

Micromethods - Automated µSPE Cleanup for High-Throughput QuEChERS Analysis

If you're looking for ways to improve your analysis of complex matrices or trace contaminants, these expert-led sessions are for you

Tired of manual uSPE? See how a fully automated, miniaturized µSPE workflow provides a superior cleanup for tough matrices like fats, oils, and spices, helping you reduce instrument maintenance and improve reproducibility.

Webinars

Webinar Series Modernizing GC/MS Workflows

Analytical precision is often compromised long before the sample reaches the detector. While instrumental sensitivity has reached historic heights, technical noise introduced during sampling, liquid handling, and inadequate storage remains the primary bottleneck for reproducible research. Every scientist knows the frustration of a perfectly calibrated instrument producing a noisy dataset due to variables outside the detector’s reach. Join PAL System, Thermo Fisher Scientific, and RECETOX to explore the transition from manual batch processing to automated robotic reliability.

ISCC 2026 Fully Automated Workflow for High-Throughput Analysis of Volatile PFAS in Food Contact Materials

Posters

ISCC 2026 Fully Automated Workflow for High-Throughput Analysis of Volatile PFAS in Food Contact Materials

Here we establish a high-throughput workflow for the quantification of 34 volatile PFAS in food contact materials (FCMs), achieving method detection limits (MDLs) of 1ug/kg for 25 target compounds. By utilizing a PAL RTC for automated internal standard addition and solvent extraction, we eliminated manual handling errors, resulting in better reproducibility (%RSD <10% at medium QC levels). Coupled with Agilent 8890 GC and 7010D GC/TQ, this system provides a robust solution for routine, unattended monitoring of grease-resistant packaging.

EPRW 2026 Optimizing Automated μ-SPE Cleanup for GC-MS/MS Analysis of Pesticide Residues in Highly Complex Food Matrices

Posters

EPRW 2026 Optimizing Automated μ-SPE Cleanup for GC-MS/MS Analysis of Pesticide Residues in Highly Complex Food Matrices

Standard commercial μ-SPE cartridges (designed for fruit/veg) lack the capacity to handle complex matrices
like cereals and oilseeds, leading to cartridge overloading.
Increasing Primary Secondary Amine (PSA) sorbent (up to 48 mg) effectively removes problematic fatty
acids from wheat, linseeds, and crickets.
High-efficiency cleanup can be "too clean" causing susceptible pesticides (e.g., Cypermethrin) to be lost to
active site adsorption in the GC system.
Analytical Matrix Shielding via a 1:1 dilution with blank tomato extract restores recoveries without
reintroducing simple lipids. This can be replaced with the addition of more standardized analytical protectants,
i.e., shikimic acid.

ASMS 2026 - Optimizing Preconcentration of Volatile PFAS Precursors: A Comparative Study of SPME Arrow and Fiber Geometries

Posters

ASMS 2026 - Optimizing Preconcentration of Volatile PFAS Precursors: A Comparative Study of SPME Arrow and Fiber Geometries

Achieving parts-per-trillion sensitivity for environmental contaminants requires both optimized extraction and absolute timing. We compared SPME Arrow and Fiber geometries for volatile PFAS precursors and found that the Arrow provides a tenfold improvement in sensitivity for compounds like 4:2 FTOH. However, our data reveals that success depends on precise extraction timing to manage competitive adsorption, where higher-affinity analytes can displace volatile targets in multi-component mixtures. Automated handling ensures these chemical interactions are managed with total reproducibility, providing a clear analytical advantage for ultra-trace quantification.

ASMS 2026 - Evaluation of Automated Derivatization and AI-Driven Data Interpretation for High-Throughput GC-MS Analysis

Posters

ASMS 2026 - Evaluation of Automated Derivatization and AI-Driven Data Interpretation for High-Throughput GC-MS Analysis

Efficiency in the modern lab now extends from the bench directly to the data suite. Our research also evaluates a comprehensive "lab-to-data" workflow that integrates "just-in-time" robotic sample preparation with AI-driven spectral interpretation. By ensuring identical incubation times for every sample, the PAL System minimizes the variability and artifact formation often seen with manual batch processing. When paired with automated feature extraction and annotation, this approach significantly accelerates the transition from raw samples to biological insights without sacrificing reliability.

ASMS 2026 Automated Two-Step Derivatization Workflow for Untargeted Metabolomics of Murine Wound Samples Using GC-ecTOF

Posters

ASMS 2026 Automated Two-Step Derivatization Workflow for Untargeted Metabolomics of Murine Wound Samples Using GC-ecTOF

High-performance metabolomics does not require a complex instrument setup. Here, we are demonstrating a refined two-step MeOx/MSTFA derivatization workflow for murine wound exudates using a standard PAL RSI configuration. By utilizing a single Agitator and a single liquid tool at a constant 37°C, we have simplified the hardware requirements while maintaining the high data quality necessary for profiling organic and amino acids. This streamlined approach proves that modular, standard hardware can master intricate biological protocols and provide a replicable blueprint for routine research.

Technical Information / Specifications

Safety Information and Warnings for Users of the PAL System

This safety guide raises awareness of potential safety issues and general points for consideration for CTC Analytics representatives during installation and repair of the PAL System or parts of it (following the life cycle principle), as well as for the end user in the lab during the learning phase and in routine work.

It is important to read this section first before operating the PAL System.

Automated Calibration Curve Preparation - Introducing the PAL Pipette Tool with Liquid Level Detection and Fliptube Manipulation

Application Notes

Automated Calibration Curve Preparation - Introducing the PAL Pipette Tool with Liquid Level Detection and Fliptube Manipulation

Pipetting is the "workstation" of the analytical laboratory - a fundamental task that, despite its routine nature, remains a significant source of the "known unknown": operator variability. In this study, we evaluate the newly launched PAL Pipette Tool LLD FT, the next-generation of the reliable PAL Pipette Tool.

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