Chronos Software for Efficient Operation of PAL Systems

ASMS 2025 - Streamlined Analysis of Polar and Non-Polar Metabolites in Plasma Using Automated Micro-SPE LC/MS

This poster presents two use cases for streamlined lipid profiling in plasma using automated Micro Solid Phase Extraction (μSPE). Where the workflows on NIST (SRM 1950) plasma samples was tested, with spiked internal standard (Ultimate SPLASH ONE) and optimized the extraction and elution parameters. Briefly, it focused on two cartridge sorbent types Mixed-Mode Cation Exchange (MCX) and C18 (CEC) and showcased their usage.

ASMS 2025 - Fully automated implementation of EPA Method 1633 for LC-MS/MS analysis of PFAS in environmental samples using a customized robotic autosampler

Posters

ASMS 2025 - Fully automated implementation of EPA Method 1633 for LC-MS/MS analysis of PFAS in environmental samples using a customized robotic autosampler

Widespread use and persistence of PFAS has led to ubiquitous detection in water, soil, air, and living organisms.
US EPA Method 1633 is intended for analysis of PFAS in aqueous, solid and tissue samples using LCMS/ MS at part-per-trillion concentrations.
This method involves significant sample preparation and purification steps prior to instrumental analysis, leading to bottlenecks in sample processing.
We have developed a fully automated, online μSPE-LC-MS/MS workflow based on a customized LC TriPlus RSH SMART Advanced system for high-throughput analysis of PFAS in environmental samples following EPA Method 1633 guidelines

eBooks

Sample Preparation Compendium

Automated, Green, and Efficient
A Compendium on Micromethods in Analytical Sample Preparation

Discover robust, precise, and reliable analytical methods while following the principles of Green Analytical Chemistry in various fields such as Food & Food Safety, Environmental, Clinical, Life Science, and Chemical.

Automated Sample Prep Workflows: Save money and time

eBooks

Automated Sample Prep Workflows: Save money and time

This compendium on instrumental sample preparation showcases the many proven solutions of automated sample preparation workflows for food, environmental, pharma, life science analysis, and beyond.

Standardized - From Study Design to Multi-Omics Integration in Metabolomics Workflows

Webinars

Standardized - From Study Design to Multi-Omics Integration in Metabolomics Workflows

We will discuss common pitfalls, things to look out for, especially in the pre-analytical phase, extractions (from monophasic to biphasic extractions) and talk about the integration of different -omics.

At a glance:

Challenges in metabolomics sample preparation and studies
Significance of standardized protocols and automation
Integration of metabolomics and proteomics workflows

Webinars

Advancing PFAS Analysis - Robotic Automation and Streamlined LC/MS Workflows

To support the scientific community and advance PFAS analysis we are proud to offer a webinar on this topic.

Key topics:

PFAS Fundamentals: Learn about the chemistry and significance of PFAS compounds.
Sample Preparation Challenges: Understand current hurdles, regulations and best practices in PFAS extraction and purification.
Automated LC/MS Workflows: Get an overview on automated workflows and see how PAL System integrates with LC/MS to optimize sample preparation and injection.
Deep Dive: Explore online SPE for PFAS analysis.

High-Sensitivity PFAS Determination in Seafood

Application Notes

High-Sensitivity PFAS Determination in Seafood

This application note showcases a fully automated workflow for the precise quantification of 73 PFAS in seafood. Utilizing a PAL RTC autosampler and Agilent triple quadrupole LC/MS system (LC/TQ), the method automates calibration, QuEChERS extraction, and μSPE clean-up.

Trace-level Volatile Organic Pollutants in Water

Application Notes

Trace-level Volatile Organic Pollutants in Water

This application note demonstrates the analysis of tracelevel volatile organic compounds (VOCs) in water using
an automated headspace-trap GC/MS workflow.
• Ultra-low detection limits (ppt) for confident quantitation of VOCs.
• Exceptional linearity and precision for accurate and reliable results.
• High performance exceeding regulatory standards for water quality.

Walk away QuEChERS extracts clean-up

See this detailed video of the uSPE workflow for the clean-up of raw pesticides extract. The PAL uSPE Cartridge is operated in scavenger mode eluting the pesticides in a clean extract. The matrix is kept on the sorbent material. The cleaned extract can be injected without waiting time online for LC/MS or GC/MS analysis. All samples are treated on the same time axis for highest reliability.

Flyer

PFAS LCMS

Discover how to automate your PFAS Analysis

Brochures

Switch from PAL-xt to PAL RSI

Modernize your Laboratory Transform your Research

Brochures

PAL3 Thermal Mixer

PAL3 Thermal Mixer – Temperature controlled heating and
mixing for well plates to boost your sample prep efficiency.

Manuals

PAL3 User Manual in Chinese

Edition 11.1

Manuals

PAL Installation Quick Reference Guide

Edition 11

Technical Information / Specifications

Specifications PAL RTC / RSI including Series II (LC & GC)

Technical Information / Specifications

PAL3 LC Tips and Hints

for PAL LC-Systems

Agilent ChemStation	Agilent GC + LC MassHunter
Agilent EZChrom	Agilent OpenLab
Bruker MS Workstation, HyStar, Compass	DataApex Clarity
GL Science Evolution Workstation	Justice Chromperfect
Shimadzu GCMSSolutions	Shimadzu LabSolutions
Sciex Analyst + SciexOS	Thermo Omnic
Thermo Xcalibur	Waters MassLynx

Chronos Software for Efficient Operation of PAL Systems

Chronos Software for Efficient Operation of PAL Systems

Chronos Software the easy to use routine software

Chronos Software Supported CDS and MS-Data Systems

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