A single-sample workflow for joint metabolomic and proteomic analysis ofclinical specimens
Integrating proteomic and metabolomic data enhances ourunderstanding of biological processes and diseasemechanisms. Traditional multi-omics workflows often requireseparate sample processing, leading to increased variability.To address this, we developed MTBE-SP3, an optimizedsingle-sample workflow that combines a 75% EtOH/MTBEmetabolite extraction with automated single-pot solid-phase-enhanced sample preparation for proteins.
ASMS 2025 - Automating Sample Preparation for High-Throughput Metabolomic Profiling. Using the MxP® Quant 500 kit and TriPlus RSH Autosampler
The analysis of small molecules and lipids in blood offers insights into systemic physiological and pathological states. Accurate metabolite quantification is essential to detect metabolic alterations associated with health, nutrition anddisease status and therapeutic interventions, underpinning biomarker discovery and precision medicine. Achieving reliable and consistent metabolite quantification in complex biofluids such as blood serum and plasma requires standardized sample handling and analytical workflows.
Sample Preparation Compendium
Automated, Green, and Efficient
A Compendium on Micromethods in Analytical Sample Preparation
Discover robust, precise, and reliable analytical methods while following the principles of Green Analytical Chemistry in various fields such as Food & Food Safety, Environmental, Clinical, Life Science, and Chemical.
Automated Parallel Derivatization of Metabolites
For metabolite profiling chemical derivatization has been used to improve MS sensitivity and LC retention. However, for multi-analytes quantification, the number of available isotopically labelled internal standards is limited. And, there is no single workflow which can provide large-scale metabolomics coverage in particular for polar metabolites.
Presented by:
Prof. Gerard Hopfgartner, Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva
Automated Sample Preperation for LC/MS and GC/MS - Solutions for Food and Environmental Analysis
In this presentation we want to discuss an important development and a demand from analytical laboratories about the standardization and the automation of sample preparation procedures for food safety, environmental, the forensic or pharmaceutical analysis.
Presented by:
Hans-Joachim Huebschmann, PhD
