衍生反应是许多色谱方法中经典的样品制备步骤。人工衍生通常需要几个处理步骤，通常涉及危险试剂。PAL System在分析前以提前样品准备模式
提供实时衍生，为大样本系列提供最佳再现性，尤其是代谢组学分析所需的再现性。
Figure 1: Directed evolution of a genetically encoded immobilized lipase for the efficient production of biodiesel from waste cooking oil
Author: Bradley S. Heater et al
Publication: Biotechnology for Biofuels & Bioproducts
Publisher: Springer Nature
Date: Jun 28, 2019 (http://creativecommons.org/licenses/by/4.0/)
Automated Parallel Derivatization of Metabolites
For metabolite profiling chemical derivatization has been used to improve MS sensitivity and LC retention. However, for multi-analytes quantification, the number of available isotopically labelled internal standards is limited. And, there is no single workflow which can provide large-scale metabolomics coverage in particular for polar metabolites.
Presented by:
Prof. Gerard Hopfgartner, Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva
Automated Sample Preperation for LC/MS and GC/MS - Solutions for Food and Environmental Analysis
In this presentation we want to discuss an important development and a demand from analytical laboratories about the standardization and the automation of sample preparation procedures for food safety, environmental, the forensic or pharmaceutical analysis.
Presented by:
Hans-Joachim Huebschmann, PhD
Automated Determination of Fatty Acid Methyl Esters using a Method developed by PAL Method Composer
An efficient method for the generation and GC-analysis of FAME was generated using PAL Method Composer ver. 1.4. PAL Method Composer allows to rapidly generate methods by simple drag & drop operations.
Automated Workflow for the determintation of Fatty Acid Methyl Esters (FAME)
This work presents a fully automated workflow using a workstation with robotic tool change (RTC based on a method using sodium methoxide in methanol as reactant .The workflow improves process safety, optimizes throughput and minimizes handling error.
Metabolite Profiling by Automated Methoximation and Silylation
A standardized automated workflow is suggested using a regular industry-standard x,y,z-robotic system for the individual derivatization steps at different reaction temperatures. The reagent addition, timing of the derivatization steps and analysis are controlled by the robotic system.
