ASMS 2025 - Streamlined Analysis of Polar and Non-Polar Metabolites in Plasma Using Automated Micro-SPE LC/MS
This poster presents two use cases for streamlined lipid profiling in plasma using automated Micro Solid Phase Extraction (μSPE). Where the workflows on NIST (SRM 1950) plasma samples was tested, with spiked internal standard (Ultimate SPLASH ONE) and optimized the extraction and elution parameters. Briefly, it focused on two cartridge sorbent types Mixed-Mode Cation Exchange (MCX) and C18 (CEC) and showcased their usage.
ASMS 2025 - Fully automated implementation of EPA Method 1633 for LC-MS/MS analysis of PFAS in environmental samples using a customized robotic autosampler
Widespread use and persistence of PFAS has led to ubiquitous detection in water, soil, air, and living organisms.
US EPA Method 1633 is intended for analysis of PFAS in aqueous, solid and tissue samples using LCMS/ MS at part-per-trillion concentrations.
This method involves significant sample preparation and purification steps prior to instrumental analysis, leading to bottlenecks in sample processing.
We have developed a fully automated, online μSPE-LC-MS/MS workflow based on a customized LC TriPlus RSH SMART Advanced system for high-throughput analysis of PFAS in environmental samples following EPA Method 1633 guidelines
This eBook explores the potential of uSPE to transform analytical workflows. It highlights the key benefits of uSPE, compares it with traditional techniques and examines its application across various industries. This resource provides a comprehensive guide for scientists and lab managers looking to optimize their sample preparation processes, achieve higher precision and embrace sustainable practices in analytical chemistry.
Automated Sample Prep Workflows: Save money and time
This compendium on instrumental sample preparation showcases the many proven solutions of automated sample preparation workflows for food, environmental, pharma, life science analysis, and beyond.
Standardized - From Study Design to Multi-Omics Integration in Metabolomics Workflows
We will discuss common pitfalls, things to look out for, especially in the pre-analytical phase, extractions (from monophasic to biphasic extractions) and talk about the integration of different -omics.
At a glance:
Challenges in metabolomics sample preparation and studies
Significance of standardized protocols and automation
Integration of metabolomics and proteomics workflows
Advancing PFAS Analysis - Robotic Automation and Streamlined LC/MS Workflows
To support the scientific community and advance PFAS analysis we are proud to offer a webinar on this topic.
Key topics:
PFAS Fundamentals: Learn about the chemistry and significance of PFAS compounds.
Sample Preparation Challenges: Understand current hurdles, regulations and best practices in PFAS extraction and purification.
Automated LC/MS Workflows: Get an overview on automated workflows and see how PAL System integrates with LC/MS to optimize sample preparation and injection.
Headspace Analysis: Reproducibility of Syringe Headspace Injections for Aqueous Samples
This article describes the optimization of residual solvents analysis according USP <467> and Ph.Eur. 2.4.24 using the automated syringe headspace technique on GC-FID and GC-MS systems. The precision of analysis ranged from 4.3 to 7.8 % RSD (GC-FID) for class 2 solvents for all analytes investigated in this study. These values fully comply with USP <467> and Ph. Eur. 2.4.24 requirements.
This application note showcases a fully automated workflow for the precise quantification of 73 PFAS in seafood. Utilizing a PAL RTC autosampler and Agilent triple quadrupole LC/MS system (LC/TQ), the method automates calibration, QuEChERS extraction, and μSPE clean-up.