This poster presents two use cases for streamlined lipid profiling in plasma using automated Micro Solid Phase Extraction (μSPE). Where the workflows on NIST (SRM 1950) plasma samples was tested, with spiked internal standard (Ultimate SPLASH ONE) and optimized the extraction and elution parameters. Briefly, it focused on two cartridge sorbent types Mixed-Mode Cation Exchange (MCX) and C18 (CEC) and showcased their usage.

• Widespread use and persistence of PFAS has led to ubiquitous detection in water, soil, air, and living organisms.
• US EPA Method 1633 is intended for analysis of PFAS in aqueous, solid and tissue samples using LCMS/ MS at part-per-trillion concentrations.
• This method involves significant sample preparation and purification steps prior to instrumental analysis, leading to bottlenecks in sample processing.
• We have developed a fully automated, online μSPE-LC-MS/MS workflow based on a customized LC TriPlus RSH SMART Advanced system for high-throughput analysis of PFAS in environmental samples following EPA Method 1633 guidelines

Gas Chromatography coupled with Triple Quadrupole Mass Spectrometry (GC/TQ) offers a robust and sensitive method for
detecting volatile PFAS. However, manual sample preparation could pose a bottleneck, impacting lab productivity. This study presents a robust and fully automated method using the PAL3 platform with GC/TQ for quantifying more than 30 volatile PFAS in FCMs, such as paper coffee cups. The automation approach minimizes human error, improving reliability
and reproducibility for routine analysis and safety assessments of PFAS in FCMs.

Automated, Green, and Efficient
A Compendium on Micromethods in Analytical Sample Preparation

Discover robust, precise, and reliable analytical methods while following the principles of Green Analytical Chemistry in various fields such as Food & Food Safety, Environmental, Clinical, Life Science, and Chemical.

This eBook explores the potential of uSPE to transform analytical workflows. It highlights the key benefits of uSPE, compares it with traditional techniques and examines its application across various industries. This resource provides a comprehensive guide for scientists and lab managers looking to optimize their sample preparation processes, achieve higher precision and embrace sustainable practices in analytical chemistry.

This compendium on instrumental sample preparation showcases the many proven solutions of automated sample preparation workflows for food, environmental, pharma, life science analysis, and beyond. 

We will discuss common pitfalls, things to look out for, especially in the pre-analytical phase, extractions (from monophasic to biphasic extractions) and talk about the integration of different -omics.

At a glance:

• Challenges in metabolomics sample preparation and studies
• Significance of standardized protocols and automation
• Integration of metabolomics and proteomics workflows

To support the scientific community and advance PFAS analysis we are proud to offer a webinar on this topic.

Key topics:

• PFAS Fundamentals: Learn about the chemistry and significance of PFAS compounds.
• Sample Preparation Challenges: Understand current hurdles, regulations and best practices in PFAS extraction and purification.
• Automated LC/MS Workflows: Get an overview on automated workflows and see how PAL System integrates with LC/MS to optimize sample preparation and injection.
• Deep Dive: Explore online SPE for PFAS analysis.

Would you like to automate your sample preparation workflow or injection (LC or GC)?

This article describes the optimization of residual solvents analysis according USP <467> and Ph.Eur. 2.4.24 using the automated syringe headspace technique on GC-FID and GC-MS systems. The precision of analysis ranged from 4.3 to 7.8 % RSD (GC-FID) for class 2 solvents for all analytes investigated in this study. These values fully comply with USP <467> and Ph. Eur. 2.4.24 requirements.

This application note showcases a fully automated workflow for the precise quantification of 73 PFAS in seafood. Utilizing a PAL RTC autosampler and Agilent triple quadrupole LC/MS system (LC/TQ), the method automates calibration, QuEChERS extraction, and μSPE clean-up.

This application note demonstrates the analysis of tracelevel volatile organic compounds (VOCs) in water using
an automated headspace-trap GC/MS workflow.
• Ultra-low detection limits (ppt) for confident quantitation of VOCs.
• Exceptional linearity and precision for accurate and reliable results.
• High performance exceeding regulatory standards for water quality.

See this detailed video of the uSPE workflow for the clean-up of raw pesticides extract. The PAL uSPE Cartridge is operated in scavenger mode eluting the pesticides in a clean extract. The matrix is kept on the sorbent material. The cleaned extract can be injected without waiting time online for LC/MS or GC/MS analysis. All samples are treated on the same time axis for highest reliability.

Discover how to automate your PFAS Analysis

Easily switch form SPME Fiber to SPME Arrow without changing the Tool.

Modernize your Laboratory Transform your Research

PAL3 Thermal Mixer – Temperature controlled heating and
mixing for well plates to boost your sample prep efficiency.

Equip your PAL Systems for PFAS Analysis with Upgrade Kits and minimize PFAS Background.

Chiew Mei Chong1, Hans-Joachim Hübschmann2

1 CTC Analytics Pte. Ltd., Singapore.
2 HANS Analytical Solutions, Osaka, Japan.

Maintaining and preparing your syringe are two of the most important aspects to guarantee your PAL System can provide reliable results. This Article shows you the tips and tricks to adequately preapre your syringe for use as well as to prolong the lifetime.

General Information for PAL SPME Fibers

General Information for PAL Smart SPME Fibers

Edition 4

Edition 11.1

Edition 3

Our products convince through quality and innovation. We implement demanding development projects. In doing so, we maintain active cooperation with technology partners, suppliers and universities. We align our company processes with the ISO standard EN 13485.

CTC Analytics supports the goal of ending violence, human rights violations and environmental devastation in the Covered Countries. We are committed to complying with all requirements applicable to our Company under the Conflict Minerals Rule. CTC Analytics complies with US - Dodd-Frank Act known as the ''Conflict Minerals Rule".

CTC Analytics processes have incorporated the results from internal and external evaluation to ensure compliance with the EU RoHS regulation.

The performance of SPME Fibers is an essential aspect of an analytical method. This study shows the comparison of three different SPME Fibers of a conventional brand  and the new PAL SPME Fibers.

for PAL LC-Systems

Sustainability is a key part of our strategy/values -this already since the foundation of the company in 1984. It is deeply anchored in our business activities and investment decision-making. Our commitment goes far beyond compliance with legal requirements. We are convinced that a careful use of resources is key to our long-term success. Consequently, we live a very sustainable culture in our company, which shapes the decisions and behavior of our employees.