PAL3-LCMS250VP-PFCFr-S
PAL3-LCMS250VP-PFCFr-X
PAL3-TH-SLCMS-AWC-250
PAL3-ActWashCup-2ChV
ASMS 2025 - Automating Sample Preparation for High-Throughput Metabolomic Profiling. Using the MxP® Quant 500 kit and TriPlus RSH Autosampler
The analysis of small molecules and lipids in blood offers insights into systemic physiological and pathological states. Accurate metabolite quantification is essential to detect metabolic alterations associated with health, nutrition anddisease status and therapeutic interventions, underpinning biomarker discovery and precision medicine. Achieving reliable and consistent metabolite quantification in complex biofluids such as blood serum and plasma requires standardized sample handling and analytical workflows.
Untargeted 2DxLC-Mass Spectrometry using SWATH-DIA-Based Workflow for the Characterization of Lipid Profiles in Plasma Samples
The use of lipidomic analyses based on LC-mass spectrometry has become widespread due to its sensitivity and specificity which provides a broader picture of lipid profiles in biofluids. In this work, we combined an automated sample extraction and a two-dimensional liquid chromatography (2DxLC) system with HILIC-based class separation followed by an orthogonal reverse-phase chromatography with an untargeted SWATH-DIA workflow to accurately annotate phosphatidylcholines (PC), lysophosphatidylcholine (LPC) and etherphosphatidylcholines (PC O-) in human plasma samples.
Minimizing Carry-over for High Throughput Analysis
Carry-over is the appearance of an analyte signal in a blank after the analysis of samples with higher analyte concentrations. It is compound and method dependent. Minimal carry-over is an important quality criterion of modern auto sampler technology and critical in HT-Analysis. In this study a strategy to minimize carry-over for HT-analysis was developed.
Sample Preparation Compendium
Automated, Green, and Efficient
A Compendium on Micromethods in Analytical Sample Preparation
Discover robust, precise, and reliable analytical methods while following the principles of Green Analytical Chemistry in various fields such as Food & Food Safety, Environmental, Clinical, Life Science, and Chemical.
Advancing PFAS Analysis - Robotic Automation and Streamlined LC/MS Workflows
To support the scientific community and advance PFAS analysis we are proud to offer a webinar on this topic.
Key topics:
Challenges and Opportunities of Sample Preparation for Complex Matrices in Liquid Chromatography coupled with Mass Spectrometer
This presentation focuses on Sample Preparation aspecting in Metabolomics and Lipidomics
Presented by:
David Ruskic and Prof. Gerard Hopfgartner, Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva
Automated Parallel Derivatization of Metabolites
For metabolite profiling chemical derivatization has been used to improve MS sensitivity and LC retention. However, for multi-analytes quantification, the number of available isotopically labelled internal standards is limited. And, there is no single workflow which can provide large-scale metabolomics coverage in particular for polar metabolites.
Presented by:
Prof. Gerard Hopfgartner, Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva
High-Sensitivity PFAS Determination in Seafood
This application note showcases a fully automated workflow for the precise quantification of 73 PFAS in seafood. Utilizing a PAL RTC autosampler and Agilent triple quadrupole LC/MS system (LC/TQ), the method automates calibration, QuEChERS extraction, and μSPE clean-up.
New Biopharmaceuticals: Bispecific Antibody Clone Selection
Herein, we describe the development of a new high-throughput approach based on the newly introduced SampleStream Platform for performing clone selection screening, enabling selection of clones that produce the highest amount and quality of the correctly assembled bispecific antibody.
