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ASMS 2025 - Streamlined Analysis of Polar and Non-Polar Metabolites in Plasma Using Automated Micro-SPE LC/MS

This poster presents two use cases for streamlined lipid profiling in plasma using automated Micro Solid Phase Extraction (μSPE). Where the workflows on NIST (SRM 1950) plasma samples was tested, with spiked internal standard (Ultimate SPLASH ONE) and optimized the extraction and elution parameters. Briefly, it focused on two cartridge sorbent types Mixed-Mode Cation Exchange (MCX) and C18 (CEC) and showcased their usage.

ASMS 2025 - Fully automated implementation of EPA Method 1633 for LC-MS/MS analysis of PFAS in environmental samples using a customized robotic autosampler

Posters

ASMS 2025 - Fully automated implementation of EPA Method 1633 for LC-MS/MS analysis of PFAS in environmental samples using a customized robotic autosampler

Widespread use and persistence of PFAS has led to ubiquitous detection in water, soil, air, and living organisms.
US EPA Method 1633 is intended for analysis of PFAS in aqueous, solid and tissue samples using LCMS/ MS at part-per-trillion concentrations.
This method involves significant sample preparation and purification steps prior to instrumental analysis, leading to bottlenecks in sample processing.
We have developed a fully automated, online μSPE-LC-MS/MS workflow based on a customized LC TriPlus RSH SMART Advanced system for high-throughput analysis of PFAS in environmental samples following EPA Method 1633 guidelines

ASMS 2025 - Fully Automated Workflow for Volatile PFAS Analysis in Food Contact Materials Using GC-Triple Quadrupole

Posters

ASMS 2025 - Fully Automated Workflow for Volatile PFAS Analysis in Food Contact Materials Using GC-Triple Quadrupole

Gas Chromatography coupled with Triple Quadrupole Mass Spectrometry (GC/TQ) offers a robust and sensitive method for
detecting volatile PFAS. However, manual sample preparation could pose a bottleneck, impacting lab productivity. This study presents a robust and fully automated method using the PAL3 platform with GC/TQ for quantifying more than 30 volatile PFAS in FCMs, such as paper coffee cups. The automation approach minimizes human error, improving reliability
and reproducibility for routine analysis and safety assessments of PFAS in FCMs.

ASMS 2025 - Fully Automated Sensitive Quantitation of PFAS in Seafood for Regulatory Screening Using Triple Quadrupole LC/MS

Posters

ASMS 2025 - Fully Automated Sensitive Quantitation of PFAS in Seafood for Regulatory Screening Using Triple Quadrupole LC/MS

Detecting trace PFAS level is challenging due to complex sample preparation like QuEChERS extraction followed by SPE cleanup, and evaporation/reconstitution. The manual steps can be labor-intensive and error-prone, affecting accuracy and reliability. This study developed a fully automated workflow for PFAS quantitation in seafood – shrimp.

ASMS 2025 - From Sample to Species - Automated MALDI-TOF MS Workflows for Streamlined Bacterial Identification

Posters

ASMS 2025 - From Sample to Species - Automated MALDI-TOF MS Workflows for Streamlined Bacterial Identification

Rapid and accurate bacterial identification is crucial in fields such as clinical diagnostics and food safety, yet traditional methods are often slow. MALDI-TOF MS offers apowerful alternative, but sample preparation is a bottleneck. We propose an automated workflow using a robotic platform to streamline this process. This automated MALDI-TOF MS workflow enhances bacterial identification by reducing manual steps and improvingstandardization across applications.

ASMS 2025 - Automating Sample Preparation for High-Throughput Metabolomic Profiling. Using the MxP® Quant 500 kit and TriPlus RSH Autosampler

Posters

ASMS 2025 - Automating Sample Preparation for High-Throughput Metabolomic Profiling. Using the MxP® Quant 500 kit and TriPlus RSH Autosampler

The analysis of small molecules and lipids in blood offers insights into systemic physiological and pathological states. Accurate metabolite quantification is essential to detect metabolic alterations associated with health, nutrition anddisease status and therapeutic interventions, underpinning biomarker discovery and precision medicine. Achieving reliable and consistent metabolite quantification in complex biofluids such as blood serum and plasma requires standardized sample handling and analytical workflows.