Product Details

Sample Preparation Compendium

Automated, Green, and Efficient
A Compendium on Micromethods in Analytical Sample Preparation

Discover robust, precise, and reliable analytical methods while following the principles of Green Analytical Chemistry in various fields such as Food & Food Safety, Environmental, Clinical, Life Science, and Chemical.

Automated Sample Prep Workflows: Save money and time

eBooks

Automated Sample Prep Workflows: Save money and time

This compendium on instrumental sample preparation showcases the many proven solutions of automated sample preparation workflows for food, environmental, pharma, life science analysis, and beyond.

Webinars

Advancing PFAS Analysis - Robotic Automation and Streamlined LC/MS Workflows

To support the scientific community and advance PFAS analysis we are proud to offer a webinar on this topic.

Key topics:

PFAS Fundamentals: Learn about the chemistry and significance of PFAS compounds.
Sample Preparation Challenges: Understand current hurdles, regulations and best practices in PFAS extraction and purification.
Automated LC/MS Workflows: Get an overview on automated workflows and see how PAL System integrates with LC/MS to optimize sample preparation and injection.
Deep Dive: Explore online SPE for PFAS analysis.

Challenges and Opportunities of Sample Preparation for Complex Matrices in Liquid Chromatography coupled with Mass Spectrometer

Webinars

Challenges and Opportunities of Sample Preparation for Complex Matrices in Liquid Chromatography coupled with Mass Spectrometer

This presentation focuses on Sample Preparation aspecting in Metabolomics and Lipidomics

Presented by:
David Ruskic and Prof. Gerard Hopfgartner, Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva

Metabolomics Spotlight Talk Gerard Hopfgartner

Webinars

Automated Parallel Derivatization of Metabolites

For metabolite profiling chemical derivatization has been used to improve MS sensitivity and LC retention. However, for multi-analytes quantification, the number of available isotopically labelled internal standards is limited. And, there is no single workflow which can provide large-scale metabolomics coverage in particular for polar metabolites.

Presented by:
Prof. Gerard Hopfgartner, Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva

High-Sensitivity PFAS Determination in Seafood

Application Notes

High-Sensitivity PFAS Determination in Seafood

This application note showcases a fully automated workflow for the precise quantification of 73 PFAS in seafood. Utilizing a PAL RTC autosampler and Agilent triple quadrupole LC/MS system (LC/TQ), the method automates calibration, QuEChERS extraction, and μSPE clean-up.

New Biopharmaceuticals: Bispecific Antibody Clone Selection

Application Notes

New Biopharmaceuticals: Bispecific Antibody Clone Selection

Herein, we describe the development of a new high-throughput approach based on the newly introduced SampleStream Platform for performing clone selection screening, enabling selection of clones that produce the highest amount and quality of the correctly assembled bispecific antibody.

Improved Peak Shapes for High Organic Samples: Sandwich Injections

Application Notes

Improved Peak Shapes for High Organic Samples: Sandwich Injections

Using a sandwich injection mode with the PAL LC/MS-P Tool enables improvements in peak shape and chromatography for samples containing a high percentage organic composition when injected into a high aqueous mobile phase.

Flyer

PFAS LCMS

Discover how to automate your PFAS Analysis

Brochures

Minimize PFAS Background with PAL System Upgrade Kits

Equip your PAL Systems for PFAS Analysis with Upgrade Kits and minimize PFAS Background.

Brochures

PAL LC/MS Tools

Three new LC-MS Tools, all equipped with Smart Syringes.

Brochures

New Volumetric Pump Enhances LC/MS Injection Efficiency

Speed up, Carryover down

Untargeted 2DxLC-Mass Spectrometry using SWATH-DIA-Based Workflow for the Characterization of Lipid Profiles in Plasma Samples

Posters

Untargeted 2DxLC-Mass Spectrometry using SWATH-DIA-Based Workflow for the Characterization of Lipid Profiles in Plasma Samples

The use of lipidomic analyses based on LC-mass spectrometry has become widespread due to its sensitivity and specificity which provides a broader picture of lipid profiles in biofluids. In this work, we combined an automated sample extraction and a two-dimensional liquid chromatography (2DxLC) system with HILIC-based class separation followed by an orthogonal reverse-phase chromatography with an untargeted SWATH-DIA workflow to accurately annotate phosphatidylcholines (PC), lysophosphatidylcholine (LPC) and etherphosphatidylcholines (PC O-) in human plasma samples.

Posters

Minimizing Carry-over for High Throughput Analysis

Carry-over is the appearance of an analyte signal in a blank after the analysis of samples with higher analyte concentrations. It is compound and method dependent. Minimal carry-over is an important quality criterion of modern auto sampler technology and critical in HT-Analysis. In this study a strategy to minimize carry-over for HT-analysis was developed.

Metabolomics: Automated Bligh Dyer extraction of tissues and cells with online LC/MS analysis

Posters

Metabolomics: Automated Bligh Dyer extraction of tissues and cells with online LC/MS analysis

Here we propose to integrate an automated Bligh and Dyer extraction on a robotic system including a dual-column UHPLC-MS/MS platform for the metabolomic analysis of tissues or cells. The aqueous fraction is split and analysed sequentially at two different mobile phase pH values, whereas the lipidic fraction is analysed alternately with an extended gradient.