Clinical Analysis

Clinical

Pharmaceutical and forensic analysis deal with biological samples, typically with challenging, complex matrices. PAL Systems deliver proven workflows for the automated analysis of the active pharmaceutical ingredients, illicit drugs, toxic compounds, and also residue analysis.

Nitrosamines in active pharmaceutical products are of high concern. The fully automated sample preparation on the PAL System with liquid/liquid injection (LLE) comprises vortexing, centrifugation and evaporation for a direct injection into LC-HRMS.

The control of residual solvents in drug products applying USP 467 standard method is the most used headspace method in pharmaceutical industry. The PAL System delivers highly precise sample preparation for headspace analysis with GC/MS.

For the analysis of illicit drugs in forensic labs often urine or hair samples are subjected to automated sample preparation on the PAL System. The dried blood spot analysis (DBS) is perfectly automated on the PAL System. Also the micro-SPE (uSPE) finds application e.g. for the analysis of psychoactive substances from serum samples, illicit drug control or TDU pain management.

Workflow Solutions

Discover our and our partners ready-to-go workflows.

Automated Powder Dispensing and Processing

Precise dispensing and weighing technology in an automated workflow.

Proteomics

Automated sample preparation in the proteomics laboratory to optimize throughput and avoid handling errors.

Simultaneous Analysis of 22 Volatile Organic Compounds in Cigarette Smoke Using Gas Sampling Bags for High-Throughput Solid-Phase Microextraction
Keywords: SPME, GC-MS, VOCs, cigarette smoke
Anal Chem. 2014 Jul 15;86(14):7088-95
Determination of cotinine by LC-MS-MS with automated solid-phase extraction (open access article)
Keywords: cigarette smoke exposure, nicotin, metabolite, quantification cotinine, ITSP, µSPE, LC/MS
J. Chromatogr Sci. 2013; 52 (4) 351-6
Evaluation of a novel commercial assay for the determination of cyclosporine A, tacrolimus, sirolimus and everolimus by liquid chromatography-tandem mass spectrometric assay
Keywords: immunosuppressant, blood samples, in-vitro diagnostic (IVD)- mass spectrometric immunosuppressant assay, LC/MS
Ther Drug Monit 2013 35(1): 129-32
Pancreatic carcinoma, pancreatitis, and healthy controls: metabolite models in a three-class diagnostic dilemma
Keywords: Amino acids, marker panels, metabolomics, modeling, pancreatic cancer, LC-MS
Metabolomics (2013) 9:677-687
Pharmacokinects of intraluminally administered serum papaverine for spasm prophylaxis of the internal mammery artery
Keywords: coronary artery bypass grafting, papaverine in plasma, HTS high-throughput screening, LC-MS/MS
Heart Surg Forum. 2013 Oct, 16(5):E266-70
Standardized LC–MS/MS based steroid hormone profile-analysis
J Steroid Biochem & Mol Biol 129 (2012) 129– 138
Comparison between a high-resolution single-stage Orbitrap and a triple quadrupole mass spectrometer for quantitative analyses of drugs
Rapid Commun. Mass Spectrom. 2012, 26, 499–509
Highly selective isolation and separation of 25-hydroxyvitamin D and 3-epi-25-hydroxyvitamin D metabolites from serum.
Bioanalysis. 2012 (22):2681-91
Headspace In-Tube Extraction Gas Chromatography–Mass Spectrometry for the Analysis of Hydroxylic Methyl-Derivatized and Volatile Organic Compounds in Blood and Urine
Keywords: ITEX, GC-MS
J Analytical Toxicology, 34, 2010, 113-121
Breath biomarkers for lung cancer detection and assessment of smoking related effects - confounding variables, influence of normalization and statistical algorithms
Clin Chim Acta 411 (2010) 1637-1644
A simple automated solid-phase extraction procedure for measurement of 25-hydroxyvitamin D3 and D2 by liquid chromatography-tandem mass spectrometry
Keywords: 25-hydroxyvitamin D, ITSP, µSPE, LC/MS/MS,
Ann Clin Biochem 2009; 46: 226–230

Related Content

Automated Determination of Drugs of Abuse in Hair Samples

Application Notes

Automated Determination of Drugs of Abuse in Hair Samples

Hair testing is a powerful tool routinely used for the detection of drugs of abuse in forensic and toxicology applications.

Automated Direct Derivatization and GCMS Analysis

Application Notes

Automated Direct Derivatization and GCMS Analysis

A Robust Method for Comprehensive Metabolomic Profiling of Dried Blood Spots, Serum, and Plasma

ASMS 2025 - From Sample to Species - Automated MALDI-TOF MS Workflows for Streamlined Bacterial Identification

Posters

ASMS 2025 - From Sample to Species - Automated MALDI-TOF MS Workflows for Streamlined Bacterial Identification

Rapid and accurate bacterial identification is crucial in fields such as clinical diagnostics and food safety, yet traditional methods are often slow. MALDI-TOF MS offers apowerful alternative, but sample preparation is a bottleneck. We propose an automated workflow using a robotic platform to streamline this process. This automated MALDI-TOF MS workflow enhances bacterial identification by reducing manual steps and improvingstandardization across applications.

ASMS 2025 - Streamlined Analysis of Polar and Non-Polar Metabolites in Plasma Using Automated Micro-SPE LC/MS

Posters

ASMS 2025 - Streamlined Analysis of Polar and Non-Polar Metabolites in Plasma Using Automated Micro-SPE LC/MS

This poster presents two use cases for streamlined lipid profiling in plasma using automated Micro Solid Phase Extraction (μSPE). Where the workflows on NIST (SRM 1950) plasma samples was tested, with spiked internal standard (Ultimate SPLASH ONE) and optimized the extraction and elution parameters. Briefly, it focused on two cartridge sorbent types Mixed-Mode Cation Exchange (MCX) and C18 (CEC) and showcased their usage.

Metabolomics Spotlight Talk Gerard Hopfgartner

Webinars

Automated Parallel Derivatization of Metabolites

For metabolite profiling chemical derivatization has been used to improve MS sensitivity and LC retention. However, for multi-analytes quantification, the number of available isotopically labelled internal standards is limited. And, there is no single workflow which can provide large-scale metabolomics coverage in particular for polar metabolites.

Presented by:
Prof. Gerard Hopfgartner, Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva

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Webinars

How to save money and time doing Sample Prep

Learn about the importance of fundamental aspects of sample preparation and modern, sustainable sample preparation technologies
Find out about the latest innovations in sample preparation in environmental analysis
Learn about new materials used in sample preparation

Presented by:
Günter Boehm, PhD, VP Sample Prep Solutions, CTC Analytics AG

Automated Sample Prep Workflows: Save money and time

eBooks

Automated Sample Prep Workflows: Save money and time

This compendium on instrumental sample preparation showcases the many proven solutions of automated sample preparation workflows for food, environmental, pharma, life science analysis, and beyond.